1.[1-9]Use of 2-{[5-(2-Amino-4-oxoquinazolin-3(4H)-yl)-1,3,4-thiadiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione in the Synthesis of Novel Quinazolinone Derivatives

Chemical and Process Engineering Research www. iiste. org ISSN 2224-7467 (Paper) ISSN 2225-0913 (Online) Vol 1, 2011 1 | P a g e www. iiste. org Use of 2-{[5-(2-Amino-4-oxoquinazolin-3(4H)-yl)-1,3,4thiadiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione in the... More

Chemical and Process Engineering Research www. iiste. org ISSN 2224-7467 (Paper) ISSN 2225-0913 (Online) Vol 1, 2011 1 | P a g e www. iiste. org Use of 2-{[5-(2-Amino-4-oxoquinazolin-3(4H)-yl)-1,3,4thiadiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione in the Synthesis of Novel Quinazolinone Derivatives Khalid M Darwish (Corresponding author) Chemistry Department, Science Faculty University of Garyounis, Benghazi-Libya khaliddarwish1962@yahoo. com Maher A El-Hashash, Sameh A Rizk, Fakhry A El-Bassiouny Chemistry Department, Science Faculty Ain Shams University, Abbassia, Cairo-Egypt. Abstract The 2-{[5-(2-Amino-4-oxoquinazolin-3(4H)-yl)-1,3,4-thiadiazol-2-yl]methyl}-1H-isoindole-1,3(2H)-dione1 was synthesized and allowed to react with each of p-methoxybenzaldehyde, p-methoxyacetophenone and chloroacetyl chloride to produce the Schiff bases 2 and 3 and 2-chloro-N-(3-{5-[(1,3-dioxo-1,3-dihydro-2Hisoindol-2-yl)methyl]-1,3,4-thiadiazol-2-yl}-4-oxo-3,4-dihydroquinazolin-2-yl)acetamide 6, respe Less